Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_217f2be73fd6be0be36dd55803d3bec5 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16134 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16022 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5256 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 |
filingDate |
2021-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99aa21c35a680b19c7d02a68cea2fded http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbb8316b5fe9a2bc0317828db407852b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fec71997be5ffa2906393d70faf8e241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31fe5faf9310ea151f1adb5c08c87239 |
publicationDate |
2021-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-113481171-A |
titleOfInvention |
A recombinant influenza virus strain carrying HIV-1 gene and its preparation method and application |
abstract |
The present invention provides a recombinant influenza virus strain carrying HIV-1 gene and a preparation method and application thereof, wherein the recombinant influenza virus strain is rescued in cells by an influenza virus vector carrying HIV-1 gene through a reverse genetic system Recombinant influenza virus; the HIV-1 gene is located in the open reading frame of the modified influenza A virus NS fragment; the splice site of the modified influenza A virus NS fragment is mutated from 525-CCAGGA-530 to 525-CCCGGG-530 The 5' end of the HIV-1 gene fragment is connected with the 3 end' of the influenza A virus NS1 fragment through a linker; the 3' end of the HIV-1 gene fragment is connected with the 5' end of the NEP fragment by a linker. The recombinant influenza virus can be stably passaged in host cells or chicken embryos, and can be used for the development of HIV-1 vaccines, the development of drugs, and the production of HIV proteins by using cells or chicken embryos as bioreactors. |
priorityDate |
2021-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |