| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5443 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-20 |
| filingDate |
2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113480662-B |
| titleOfInvention |
Fusion protein comprising CD40 antibody and IL-15 and preparation method and use thereof |
| abstract |
The present invention discloses a bispecific fusion protein comprising cytokine IL-15 and CD40 antibody or immunologically active fragment, and a preparation method and use thereof. Different plasmids were co-transfected and expressed. The fusion protein disclosed in the present invention can activate APC cells, T cells and NK cells at the same time, enhance the tumor targeting of cytokines; can stimulate DC cells to mature and secrete IL-12, can significantly inhibit the growth of mouse melanoma, reduce the Melanoma volume and mean lung metastases. |
| priorityDate |
2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |