abstract |
The invention discloses an anti-HE4 nanobody, the nanobody has three unique complementarity determining regions CDR1, CDR2, CDR3, the antibody affinity can reach 1.193E-11, and can detect especially double antibody in HE4 serum Excellent detection results were obtained in the sandwich method. The present invention also provides a set of nanobody combinations for detecting HE4 by double-antibody sandwich method and the application of the antibody combination in the preparation of HE4 antigen detection kits, the combination comprises an anti-HE4 bivalent nanobody as a capture antibody and an anti-HE4 nanobody as a capture antibody Anti-HE4 monovalent Nanobody for detection antibody. |