http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113480481-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67aaca2b581f540fd09ad678a9080ded |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 |
| filingDate | 2021-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cab6b10ae129d7e848bfa6fd02f0a62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdc1130fa6fa9636ade99f47e914d95b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bc608701e71237196f77ec41ba72a9d |
| publicationDate | 2021-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113480481-A |
| titleOfInvention | A kind of preparation method of degraded impurities in ivabradine hydrochloride |
| abstract | The invention provides a preparation method for degrading impurities in ivabradine hydrochloride, comprising the following steps: 1) compound 2 is prepared by Riley oxidation reaction to prepare compound 3; 2) compound 3 and compound 4 are prepared by condensation in the presence of a condensing agent Compound 5 is obtained; 3) Compound 5 is deprotected from acetal in acidic aqueous solution to obtain compound 6; 4) Compound 6 is prepared by catalytic hydrogenation reduction to obtain compound 7; 5) Compound 7 and compound 8 undergo nucleophilic substitution reaction Compound 9 is prepared; 6) Compound 9 is prepared by reduction reaction to obtain compound 1. The yield of the degraded impurity in Formula 1 prepared by the method of the present invention is 40.9%, and the purity reaches 99.865%. It can be applied to the process research, stability research, quality research and establishment of quality standards of ivabradine hydrochloride to provide technical support for the safety of ivabradine hydrochloride. |
| priorityDate | 2021-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.