| abstract |
The invention belongs to the field of organic synthesis, and discloses a method for synthesizing alpha-fluoroacrylate, which takes aldehyde and diethyl fluoromalonate as raw materials, and reacts in tetrahydrofuran solvent under the conditions of magnesium chloride, N-diisopropylethylamine and microwave heating according to the following reaction formula to obtain the alpha-fluoroacrylate compound with Z configuration. The alpha-fluoroacrylate synthesized by the method has the advantages of simple reaction operation, high reaction yield and high cis-trans ratio of the product olefin. The reagents required by the reaction are cheap, and the reagents with high toxicity and expensive metal catalysts are not required to be used. In addition, the method has wide substrate compatibility, economic method and low cost. |