| abstract |
The invention relates to the field of hydrogel materials, and discloses a preparation method of a hydrogel dressing that can be rapidly gelled and slowly strengthened after injection. obtain aldehyde modified polysaccharide macromolecules; 2) copolymerize sulfobetaine methacrylate and glycidyl methacrylate to obtain a hydrophilic copolymer containing epoxy groups; 3) combine chitosan solution, The mixed solution of the aldehyde-modified polysaccharide macromolecule and the epoxy group-containing hydrophilic copolymer is injected while being mixed to obtain a hydrogel dressing. The gel-forming method of the present invention can realize rapid gel-forming at room temperature or 37° C., and can also use the slow cross-linking of amino and epoxy groups to strengthen the network in the later stage, which makes up for the shortcoming of the insufficient strength of the injectable hydrogel itself. . In addition, the hydrogel of the present invention also has the characteristics of adjustable degradation time, self-healing, safety and non-toxicity, and can effectively promote wound healing and bone repair. |