| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67aa3bc75203266389dcde6a7cb83250 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-10 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-65 |
| filingDate |
2021-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4c855b41058fda5c1b728caf0b17b51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fa8f40b58a207e453d66413fa4ad390
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6099bcbaa016b2edf7fc35510d269210 |
| publicationDate |
2021-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113476619-A |
| titleOfInvention |
A kind of 18F-labeled nanobody probe and its preparation method and application |
| abstract |
The invention discloses an 18 F-labeled nanobody probe, a preparation method and application thereof, and relates to the fields of nuclear medicine and molecular imaging. The targeting carrier of the probe includes nanobody MM01, nanobody MM02 or a derivative of nanobody MM02 , and its preparation method is: synthesizing a small molecule compound precursor RJDJ01; preparing an 18 F-labeled precursor 18 F[F]-RJDJ01; preparing a fluorine-18 ( 18 F)-labeled nanobody probe through a click chemistry reaction; the probe is For the detection of multiple myeloma CD38-specific nanobodies. The invention realizes non-invasive visualization of CD38 expression and non-invasive detection of multiple myeloma by creating a CD38-specific novel nanobody probe 18 F[F]-MM01. The probe has the advantages of simple preparation process, low cost, high specificity, high stability, short imaging period, low radiation dose, and easy clinical transformation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114617983-A |
| priorityDate |
2021-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |