| abstract |
The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a metformin hydrochloride sustained-release tablet and a preparation method thereof. The shown metformin hydrochloride sustained-release tablet comprises the following raw material components: 20-40 parts of metformin hydrochloride, 10-20 parts of inorganic phosphate, 5-10 parts of metasilicate, 30-50 parts of hydrophilic polymer and a or 50-80 parts of multiple pharmaceutically acceptable excipients. The sustained-release effect of the present invention is based on the synergistic effect between inorganic phosphates, metasilicates and hydrophilic polymers. When combined with inorganic phosphates and metasilicates, the increase in the viscosity of the hydrophilic polymer provides a sustained release of metformin hydrochloride from tablets, with a smoother and more uniform release profile, high similarity to the reference formulation, and no There is a burst phenomenon. |