| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b12f0d44fedff92f970fb40a547058be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8528ff66470c896b6da8ed059464e31f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43563
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43595
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43518
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43536 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 |
| filingDate |
2019-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_892dccc6d14603c3183918dff8b4b280
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa74f91c57aef7dfe72f45f4b4af2c38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_553eb0da0d496f6e05f5520762deb3b6 |
| publicationDate |
2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113474357-A |
| titleOfInvention |
Fusion proteins with toxins and scaffold proteins |
| abstract |
The present invention relates to the fields of structural biology and drug discovery. More particularly, the present invention relates to novel fusion proteins, their use and methods in the analysis of the three-dimensional structure of macromolecules, such as X-ray crystallography and high resolution cryoelectron microscopy, and their use in structure-based drug design and screening, and as pharmacological tools. Even more particularly, the present invention relates to functional fusions of toxins and scaffold proteins in which a folded scaffold protein disrupts the topology of the toxin by inserting into an exposed β -turn of the toxin containing a β -chain domain to form a rigid fusion protein that retains high affinity target binding capacity. |
| priorityDate |
2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |