| abstract |
The present invention relates to a pyrazine derivative and its application in inhibiting SHP2, a compound of formula (I) or a pharmaceutically acceptable salt, ester, isomer, solvate, prodrug or isotopic label thereof , the structure of the compound of formula (I) is: The novel pyrazine derivatives provided by the present invention have excellent SHP2 inhibitory activity, and can be used for preventing and/or treating non-receptor protein tyrosine phosphatase-mediated or dependent diseases or conditions. |