| abstract |
The present invention relates to a 1,3,4-oxadiazole neuraminidase inhibitor and a preparation method and application thereof. The inhibitor has the structure shown in formula (I): The preparation method is specifically as follows: (1) reacting aniline, chloroacetyl chloride and triethylamine to obtain an intermediate of formula (II) after post-processing; (2) reacting benzoyl hydrazide, carbon disulfide and potassium hydroxide, and then performing post-processing The intermediate of formula (III) is obtained; (3) the intermediate of formula (II) and the intermediate of formula (III) are dissolved in an organic solvent, and the inhibitor represented by formula (I) is obtained by post-treatment after the reaction. Compared with the prior art, the compound of the present invention has a novel structure, and experiments show that it has a good neuraminidase inhibitory activity, and can be used to prepare a medicine for inhibiting the neuraminidase activity. |