http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113461603-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c84b71b532e3fc02117c39e57ca5202 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 |
| filingDate | 2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6afcb2978fd01daa74c539b42e8992c9 |
| publicationDate | 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113461603-A |
| titleOfInvention | Synthetic method of medicine raw material 2, 5-dibromopyridine |
| abstract | The invention relates to the technical field of dibromopyridine preparation, and discloses a synthetic method of a medicine raw material 2, 5-dibromopyridine, which comprises the following steps: s1: heating, namely adding 2-aminopyridine and acetic anhydride into a four-neck flask, heating to reflux, and tracking by thin-layer chromatography until the reaction is complete; s2: cooling, wherein the raw materials in the S1 are cooled after complete reaction, then bromoethane is added for stirring, heating is carried out during stirring, the heating temperature is 30-60 ℃, the heating time is 20-40 minutes, and cooling is carried out again after stirring to obtain a mixture A; s3: liquid bromine is added dropwise. The invention can pre-mix the raw materials, make the raw materials react preliminarily, improve the reaction effect, promote the full reaction with the mixture B, generate bubbles after the reaction, facilitate the next crystallization operation, reduce the cost by accurately controlling the temperature and the raw materials in the process, and is safer and more reliable. |
| priorityDate | 2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.