| abstract |
The invention discloses a synthesis process of glycopyrronium bromide bulk drug. The synthesis process uses dihydropyran compounds to protect a-cyclopentylmandelic acid compounds by hydroxyl group, then carries out esterification reaction, then removes the protective group, and finally Glycopyrronium bromide is obtained by quaternization reaction. The invention has mild reaction conditions, does not need to introduce a large amount of auxiliary agents and solvents, conforms to the principle of green chemistry, and is suitable for industrialization and industrialization. |