| abstract |
The invention relates to a phenoxy acid derivative and application thereof. Specifically provided is a compound represented by the formula (I-2), or a salt thereof, or a stereoisomer thereof, or a deuterated compound thereof. Experiments prove that the compound shown as the formula (I-2) is combined with a proteasome inhibitor, not only can effectively inhibit the growth of tumor cells in vitro, but also can play a synergistic antitumor activity in vivo, and has very good clinical effect in preparing medicines for treating primary or secondary drug-resistant tumors of the proteasome inhibitorPotential of the bed. |