http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113456816-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113456816-B |
| titleOfInvention | A self-oxygen-supply hollow Prussian blue nanoparticle and its preparation method and application |
| abstract | The invention discloses a self-oxygenated hollow Prussian blue nanoparticle and its preparation method and application. It has a hollow Prussian blue nanoparticle, and the mesoporous shell and internal hollow structure of the hollow Prussian blue nanoparticle are loaded with hemoglobin and IR783. Among them, the drug loading amount of hemoglobin is 61.5‑63.5%, and the drug loading amount of IR783 is 24.2‑27.5%. The self-oxygenated hollow Prussian blue nanoparticles loaded with hemoglobin and IR783 prepared by the present invention can improve the situation of insufficient oxygen supply in photodynamic therapy. In addition, the half-life of active oxygen generated by photodynamic therapy is very short, and only in a relatively short distance Effectively, the present invention transports self-oxygenated hollow Prussian blue nanoparticles loaded with hemoglobin and IR783 to the mitochondria by loading IR783 with the function of targeting mitochondria, thereby destroying mitochondrial functions, significantly improving the efficacy of photodynamic therapy, and promoting tumor cell apoptosis. |
| priorityDate | 2021-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.