http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113447654-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-705 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57434 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4748 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
filingDate | 2021-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-113447654-B |
titleOfInvention | Application of mass spectrometry technology in detecting PSM-E molecular level in urine in preparation of products for early diagnosis of prostate cancer |
abstract | The invention discloses an application of detecting PSM-E molecular level in urine by a mass spectrometry technology in preparation of a product for early diagnosis of prostate cancer. The urine protein sample is diluted and then directly introduced into a liquid chromatography-electrospray ionization-tandem mass spectrometer for determination, so that the PSM-E content level in urine can be rapidly and accurately detected; the fully-synthesized PSM-E characteristic peptide standard substance is used as an internal standard quantitative analyte, so that errors caused in the pretreatment process of a sample are reduced; the liquid chromatogram tandem mass spectrometry method has the advantages that the selectivity and the accuracy of the method are better improved; the selection and optimization of chromatographic columns and elution conditions improve the chromatographic separation process and shorten the chromatographic analysis time. The invention can realize the quantitative detection of PSM-E in the urine specimen, has simple operation and convenient application, and confirms that the PSM-E content in the urine can be used as a specific biomarker for detecting the prostatic cancer, thereby providing an efficient and feasible technical method for early screening of the prostatic cancer. |
priorityDate | 2021-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 410.