| abstract |
The present application provides compounds of any one of formulas (I) and (II). The compounds described herein are inhibitors of histone methyltransferases (e.g., enhancer of zeste homolog 1(EZH1) and enhancer of zeste homolog 2(EZH2)) and are useful in the treatment and/or prevention of a wide range of diseases (e.g., proliferative diseases). The present application also provides pharmaceutical compositions, kits, methods and uses, including or using the compounds described herein. The present application also provides methods of identifying EZH1 and/or EZH2 inhibitors. |