http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113443987-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3d7e466c44c7b54e2a48e4bf62665ef |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-618 |
| filingDate | 2021-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6c24f7c8420ce5275e7bca92fbfbba6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d29c56c84e81d4d97e7c2a9c75988131 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c7a0deac0ae6a390d2d28b584c5f053 |
| publicationDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113443987-A |
| titleOfInvention | A method for copper asymmetric catalyzed construction of chiral tetra-substituted exocyclic α-hydroxy allenoates |
| abstract | The invention belongs to the technical field of asymmetric catalysis synthesis, and specifically discloses a method for constructing a chiral tetra-substituted ring (dihydroindene ring or tetrahydronaphthalene ring) exo α-hydroxy allenoate by copper asymmetric catalysis. Using the copper/chiral oxazoline system to catalyze the intermolecular and intramolecular tandem cyclization of arylalkynals or arylalkynones with diazo compounds, optically pure tetrasubstituted rings (dihydrogen) containing central chirality and axial chirality were synthesized. Indene ring or tetrahydronaphthalene ring) exo α-hydroxy allenoate method, wherein the enantioselectivity is as high as 97% ee and the diastereoselectivity is as high as >19:1 dr. The advantages of the method of the invention are: simple and mild reaction conditions, wide application range of substrates, high yield, and good enantioselectivity and diastereoselectivity. |
| priorityDate | 2021-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.