http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113429559-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afa80f22a2246c6e8ab232c4d5a7ab83 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-3324 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-2624 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33396 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-332 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 |
| filingDate | 2020-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f47e664437c3db176fd362d807d93029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52ae23089003315251750f53da242096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1572df360e6778ec337394c49d0ea36e |
| publicationDate | 2021-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113429559-A |
| titleOfInvention | Six-arm polyethylene glycol derivative with end hetero-functionalized and preparation method thereof |
| abstract | The invention discloses a terminal heterofunctionalized six-arm polyethylene glycol derivative with a structure shown as a general formula (1) and a preparation method thereof. Wherein, 1 trivalent central structure A 0 And 3 symmetrical trivalent branched structures A 1 Jointly form a hexavalent center structure with high symmetry; l is 2 Linking trivalent branched structures A 1 And a polyethylene glycol arm; the six polyethylene glycol chains have polydispersity or monodispersity and have a degree of polymerization of n 1 ～n 6 All selected from 1 to 2000; l is 0 Is a divalent linking group which connects the PEG chain segment with the terminal trivalent branching group A 2 ；A 2 F of extraction D And F T Contain different functional groups; a. the 0 、A 1 、L 2 、L 0 、A 2 、(Z 2 ) q ‑(Z 1 ) q1 Either, or the linking groups formed by either and adjacent groups, each independently, may be stable or degradable. F D And F T One of the two can be connected with a targeting molecule, and the other can be connected with a drug molecule, thereby improving the targeting property and the curative effect of the drug. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114592348-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114592348-B |
| priorityDate | 2020-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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