http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113429417-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_378b3831badea3bf2bc3990fa3d36c5d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 |
| filingDate | 2021-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f78dfb83059cb8347ab14aa0054c48b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bc01035fb9c78e8453d9992c5399091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b6d904fed6b21224d10304bc5baeae9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4994e37a0434cae0528bbd391e5afc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15376e89f5908b5088086d20f7622869 |
| publicationDate | 2021-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113429417-A |
| titleOfInvention | A method for preparing amphiphilic compounds coupled with camptothecins and Evans blue |
| abstract | The invention provides a method for preparing an amphiphilic compound coupled with camptothecins and Evans blue, comprising: reacting camptothecin or a derivative thereof with a carbonylation reagent in an organic solvent, adding Intermediate F is formed; the hydroxyl group of intermediate F is acylated with chloroformate to generate intermediate G; o-toluidine and In the presence of a coupling reagent, amide bond coupling and condensation occurs to produce intermediate D; intermediate D and 1-amino-8-naphthol-2,4-disulfonic acid monosodium salt undergo diazotization coupling reaction to generate intermediate E; the intermediate E is deprotected to obtain the intermediate C; the intermediate C and the intermediate G undergo a nucleophilic substitution reaction in an organic solvent to generate an amphiphilic compound. The method of the present invention and the existing EB-CPT synthesis method have higher reaction efficiency, fewer side reactions and higher yield, and are more suitable for industrial production. |
| priorityDate | 2021-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.