http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113429342-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b49cacf0dfad0fa5e568f87e2f0817b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 |
| filingDate | 2021-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c54918fe5b8380c440d17517c4a98763 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a70a841ba86151d5ca25afadbd4a60d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8368cd70e89fc73a9497ced4a3ac7c65 |
| publicationDate | 2021-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113429342-A |
| titleOfInvention | Synthesis method of pexidaltinib intermediate |
| abstract | The invention provides a synthesis method of a pexidinib intermediate, which specifically comprises the following steps: taking 6-amino nicotinic acid ester compounds and 6-trifluoromethyl nicotinaldehyde as raw materials to synthesize compounds I, taking the compounds I as raw materials, and carrying out reduction reaction by using a reducing agent to generate [6- ({ [6- (trifluoromethyl) pyridin-3-yl ] methyl } amino) pyridin-3-yl ] methanol; the [6- ({ [6- (trifluoromethyl) pyridin-3-yl ] methyl } amino) pyridin-3-yl ] methanol is used as a raw material and is oxidized by an oxidant to generate 6- ({ [6- (trifluoromethyl) pyridin-3-yl ] methyl } amino) pyridine-3-formaldehyde. The synthesis method has the advantages of cheap and easily-obtained raw materials, simple and convenient operation, mild reaction conditions, high yield (the total yield is more than 58.62 percent) and the like, can realize large-scale production, and reduces the production cost of the pexidininib, thereby improving the market competitiveness of the product. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113816956-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114736204-A |
| priorityDate | 2021-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.