| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49790ed5b8ddc5fa27a1d47732c612df |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 |
| filingDate |
2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a625527d0309cf73f3e21a3112a66f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c70ac201a8d65867a93feb578ec81fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6b98b185f2e41baf9c8600d64b5b0e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9f5f78345893a19753c8a821c3263e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31c720418d76be7e1ac00572896aa454 |
| publicationDate |
2021-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113429331-A |
| titleOfInvention |
A kind of chiral indoline derivative and preparation method thereof |
| abstract |
The invention discloses a chiral hexahydroindole derivative and a preparation method thereof. The 1,3-cyclohexadienamine derivative of formula (I) is dissolved in an organic solvent and mixed with a halogenated compound at 30-40 An asymmetric Heck/Tsuji-Trost reaction is catalyzed by a palladium catalyst/chiral ligand PC-Phos(S,Rs)-P1 at ℃ to obtain a chiral indoline derivative represented by formula (II). The preparation method of the invention has mild reaction conditions and simple operation, can provide a chiral indoline structure skeleton, and is of great significance to the synthesis of substituted indoline-containing natural products. |
| priorityDate |
2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |