| abstract |
The invention provides an arsenic fluorescent quantum dot and a preparation method and application thereof. The molecular formula of the quantum dot is As 4 S 4 @HA QDs, wherein As 4 S 4 and HA are realgar and hyaluronic acid, respectively, and the arsenic fluorescent quantum dot is As 4 S 4 @HA QDs. Using hyaluronic acid as a stabilizer, a stable HA hydration film is formed on its surface; the preparation method is as follows: dissolving realgar in ethylenediamine, using hyaluronic acid as a stabilizer, and adding hydrochloric acid to adjust pH to form a form Structurally stable arsenic fluorescent quantum dots. The quantum dot of the invention is simple in preparation method and stable in structure, can track intracellular delivery in real time by means of spontaneous strong fluorescence, and specifically recognize tumor cells through hyaluronic acid ligand, realize tumor-targeted delivery, and selectively kill tumor cells. And reduce potential toxic and side effects, with broad application prospects. |