| abstract |
The present application discloses the use of a triterpenoid and its dimer compound in the preparation of a drug for treating diseases mediated by protein tyrosine phosphatase 1B. Regeneration), 7 kinds of triterpenes and their dimer compounds were isolated, and then the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity experiment was carried out on the triterpenes and their dimer compounds obtained by the above separation. It is shown that these compounds all have significant inhibitory activities, and can be used to make drugs for preventing, delaying or treating diseases mediated by PTP1B, especially type II diabetes and obesity, or as leading compounds of such drugs. |