| abstract |
The invention provides the application of an amino acid or an amino acid analog or a salt thereof as an additive for improving the solubility of allantoin and a room temperature stable solution with high allantoin content. The inventors found that after mixing amino acids or amino acid analogs or their salts, allantoin, and polar solutions in proportions, a clear solution can be prepared by heating, evaporation or freeze-drying. Water can be mixed in any ratio and allantoin is not precipitated. The clear solution prepared by the invention can not only solve the problem of poor solubility of allantoin, but also greatly improve the application efficiency and bioavailability of allantoin. |