http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113424799-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2021-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113424799-B |
| titleOfInvention | Construction method and application of a PDX model based on the modification of the osteogenic niche microenvironment |
| abstract | The invention belongs to the technical field, in particular to a construction method and application of a PDX model modified based on an "osteogenesis niche" microenvironment. The construction method is as follows: human umbilical cord mesenchymal cells are placed on biologically derived bone to induce differentiation into osteoblasts, and the biologically derived bone loaded with osteoblasts is obtained, and implanted under the skin of mice, and then primary leukemia Cells or tumor cells were seeded subcutaneously at the implantation site of biologically derived bone in mice. The present invention constructs a novel microenvironment modified PDX model, which provides a new type of PDX model with high transplantation success rate, stable passage, and can effectively retain the biological characteristics of primary cells for studying the formation mechanism of drug resistance of leukemia or tumor cells and drug screening. Disease research models. |
| priorityDate | 2021-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.