| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-258
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2509-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-1392
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2509-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3895
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3834
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3865
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0654
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate |
2021-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113413489-B |
| titleOfInvention |
Let-7 a-containing periodontal defect repair system |
| abstract |
The invention relates to the technical field of bone defect repair, in particular to a periodontal defect repair system containing Let-7 a. Comprises a third cell aggregate and hydroxyapatite-beta tricalcium phosphate coated in the third cell aggregate; the third cell aggregate is transfected with let-7a mimic; let-7a mimic is double-stranded RNA, and the sequence of the sense strand of let-7a mimic is shown in SEQ ID NO. 2. The technical problem that the effect of repairing bone defects by using periodontal ligament stem cells is poor can be solved. According to the scheme, Let-7a is used for regulating and controlling osteogenic differentiation capacity of periodontal ligament stem cells, and the periodontal defect repair system is formed by combining with a periodontal ligament stem cell polymer, so that a feasible way is provided for quick and effective repair of periodontal defects. |
| priorityDate |
2021-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |