http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113413399-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b2e4f17c10a288dc28521ed1e17a0d3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-744 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-064 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-744 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-064 |
| filingDate | 2021-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e963c5dab00dcd09612af559e85c8f68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f78cb6bad959f470fa3d58e4680cc194 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83c1c34a5c9f60bca501054dce05ff17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a8b4d6ec1fb589a1fe5532e89d3ab89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0857e161390485baec40fae2166233d1 |
| publicationDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113413399-A |
| titleOfInvention | Application of tea fungus fermentation broth in preparation of drugs for preventing or treating LPS-induced sepsis |
| abstract | The invention relates to the application of tea fungus fermentation liquid in the preparation of medicine for preventing or treating LPS-induced sepsis, wherein the sepsis is life-threatening organ dysfunction caused by the abnormal response of the body to infection, and the prevention of tea fungus fermentation liquid And the therapeutic effect is mainly manifested in the LPS-induced sepsis mouse model, the tea fungus fermentation broth can effectively alleviate the LPS-induced adverse signs such as body temperature drop, lethargy, decreased activity and appetite, etc. The survival rate of septic mice increased from 0% to 40%; it can effectively inhibit the transcription level of inflammatory factors in lung tissue; regulate immune cell function, significantly promote the expression of B cells and macrophages, and increase the proportion of T cells; Relieves the lung injury of LPS-induced sepsis; reduces the phosphorylation levels of IκBα and NF-κBp65 in lung tissue, inhibits the excessive activation of NF-κB signaling pathway, and down-regulates the expression of inflammatory factors in serum, which is expected to be useful for the prevention and treatment of sepsis. Treatment provides new strategies and clinical research basis. |
| priorityDate | 2021-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 325.