| abstract |
The invention discloses a method for determining the end point of a synthesis reaction of phenoxy cyclophosphazene. In the present invention, the synthesized phenoxy cyclophosphazene reaction solution is added to the mobile phase (acetonitrile: methanol-water (1:1)=4:1) to a constant volume, and then directly passed into the chromatographic column. After gradient elution, an ultraviolet detector Then, the ratio of the reaction intermediate and the target product is analyzed by liquid chromatography area normalization method, so that the reaction end point can be effectively judged. The present invention can directly use the reaction solution for detection. Under the detection conditions provided by the present invention, the separation between the phenoxy cyclophosphazene, the intermediate and each impurity is good, and the peak time is relatively suitable. After methodological verification, the method has the advantages of strong specificity, high accuracy, high sensitivity and good stability. |