http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113402584-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e377670a1551ae603e248095133d0a62 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34 |
| filingDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23f96c76d4f8a1ac19a88961a3e383c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfc64655310252cddcf18b5487027eee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0811cc4a5e5d3fa4cff3a65ff9c80cf8 |
| publicationDate | 2021-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113402584-A |
| titleOfInvention | A kind of synthetic method of the intermediate LND1067-L1 of antibody-conjugated drug linker |
| abstract | The present invention provides a method for synthesizing LND1067-L1, an intermediate of an antibody-drug conjugated linker. The synthesis method comprises: reacting LND1067-L1-0 with lead tetraacetate in a first solvent to prepare LND1067-L1-1; reacting LND1067-L1-1 with benzyl glycolate in THF to prepare LND1067-L1-3; LND1067-L1-0 is reacted with phenylalanine tert-butyl ester hydrochloride in the second solvent to prepare LND1067-L1-6; LND1067-L1-6 is reacted with trifluoroacetic acid in the third solvent to prepare LND1067 -L1-7; react LND1067-L1-3 with diethylamine in DMF, after concentration, add LND1067-L1-7, PyBop, diisopropylethylamine, react in the fourth solvent to prepare LND1067- L1-8; LND1067-L1-8 is reacted with palladium-carbon in the fifth solvent to prepare LND1067-L1. The synthesis method of the invention solves the problems that the original research route is small in magnitude, high in production difficulty and difficult to scale up. Through the optimization and improvement of the process, the efficient synthesis of LND1067-L1 is realized, which is easy to scale up and facilitate commercial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113527418-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113527418-B |
| priorityDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.