http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113398265-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-6852 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 |
| filingDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113398265-B |
| titleOfInvention | Preparation and application of a red light-induced singlet oxygen-responsive polymer nano-anticancer drug |
| abstract | The invention discloses the preparation and application of a red light-induced singlet oxygen-responsive polymer nanometer anticancer drug. The invention utilizes the singlet oxygen-responsive linking group of amino acrylate to covalently bridge polyethylene glycol-polycaprolactone through reactions such as esterification reaction, click reaction, ring-opening polymerization and the like. The copolymer is amphiphilic and can self-assemble and encapsulate the photosensitizer fluoroborodipyrrole (BDP) and the chemotherapeutic drug paclitaxel (PTX) in aqueous solution to obtain red light-induced singlet oxygen-responsive polymer nano-anticancer drugs (SOR‑ NP BDP/PTX ). At the same time, the present invention takes the nano anti-cancer drug (SOR-NP BDP/PTX ) as the research object, and performs in vivo light therapy on the tumor model of liver cancer-bearing mice, which lays a foundation for the application of SOR-NP BDP/PTX to cancer treatment, and the The nanomaterials and the amphiphilic polymers have simple synthetic methods and high yields, which are favorable for industrial production. |
| priorityDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.