| abstract |
The invention relates to an application of a 5-substituted derivative of a benzene ring of chlorsulfuron in preparing an anti-tumor medicament, wherein the chemical structural general formula of the 5-substituted compound of the benzene ring of chlorsulfuron is as follows: in the formula: r is selected from halogen, nitro, cyano, trifluoromethyl and halogenated C 1 ‑C 6 Alkyl radical, C 1 ‑C 6 Alkoxy, halo C 1 ‑C 6 Alkoxy radical, C 1 ‑C 6 Alkylthio, halo C 1 ‑C 6 Alkylthio radical, C 1 ‑C 6 Alkoxycarbonyl, halo C 3 ‑C 6 Cycloalkyl or N, N- (C) 1 ‑C 6 Alkyl) carbamoyl, N- (C) 1 ‑C 6 Alkyl) aminosulfonyl, N, O, S-containing ternary-five-membered heterocycles, C 1 ‑C 6 Alkyl substituted N, O, S containing ternary-five member heterocycle. The invention discovers for the first time that the benzene ring 5-substituted derivative of chlorsulfuron has the function of inhibiting breast cancer cells and can be used for preparing anti-tumor medicaments. |