| abstract |
The invention belongs to the technical field of medicinal preparations, and particularly relates to a composition for improving bioavailability of insoluble medicine crocetin, an oral preparation and a preparation method thereof. The composition for improving the bioavailability of the insoluble medicine crocetin is as follows: 1 part of insoluble drug crocetin, 1-10 parts of hydrophilic polymer carrier material and 1-10 parts of pH value regulator. The preparation method of the composition comprises the steps of carrying out ball milling on the crocetin, the hydrophilic macromolecular carrier and the pH value regulator by adopting the mechanochemical principle to obtain the crocetin composition, and then preparing the composition, a proper diluent, a disintegrant, an adhesive and a lubricant into the crocetin oral preparation according to the conventional solid preparation process. The crocetin oral preparation prepared by the invention is dissolved out quickly in vitro and absorbed quickly in vivo after being taken orally, so that the oral bioavailability of the crocetin is greatly improved, and the preparation process is simple to operate, has good reproducibility and is suitable for industrial production. |