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filingDate 2020-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_117ed7f2da5d3ec60a727a18e050fc30
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publicationDate 2021-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113390972-A
titleOfInvention A kind of HPLC method for detecting ozagrel related substances
abstract The invention discloses a method for detecting ozagrel-related substances by HPLC, and relates to the field of drug analysis. The method uses octadecylsilane bonded to a silica gel chromatographic column, uses the first phosphate solution-methanol 90-98:10-2 (V/V) as mobile phase A, and uses the second phosphate solution-methanol 20-40 : 80-60 (V/V) is mobile phase B, carry out gradient elution, and detect related substances in Ozagrel. The method can quickly and effectively separate a variety of potential trace related substances in ozagrel APIs, and has the advantages of stable baseline, beautiful peak shape, good resolution, and high durability, and can efficiently achieve a variety of related substances in ozagrel. It is suitable for the rapid quality monitoring of ozagrel raw materials in industrial large-scale production, and is of great significance for product quality control.
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