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filingDate 2021-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113390941-B
titleOfInvention Method for online enrichment determination of organic acid content based on FLM-EKS-CZE of ionic liquid coating
abstract The invention discloses a method for measuring the content of organic acid by FLM-EKS-CZE online enrichment based on an ionic liquid coating, the organic acid is vanillic acid, sodium danshensu and ferulic acid, the invention combines the free liquid film with the electric pressurization on-line enrichment technology on the basis of the ionic liquid modified coating capillary column, the electroosmotic flow direction of the capillary is reversed after the capillary is modified by the ionic liquid coating, the chemical stability is good, the separation effect on target analytes is good, and in addition, in the subsequent FLM-EKS-CZE two-step online enrichment method, the accumulation of FLM-FESI and t-ITP further improves the enrichment efficiency of target analytes, and the method has the advantages of good reproducibility, short analysis time, higher sensitivity, low detection limit and enrichment multiple of more than 2000 times, meets the requirement of green chemistry, and is suitable for measuring the content of organic acids in complex sample matrixes such as traditional Chinese medicines.
priorityDate 2021-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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