| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0325
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7158 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113388640-B |
| titleOfInvention |
CCR4 gene humanized non-human animal and its construction method and application |
| abstract |
The present invention provides a method for constructing a CCR4 gene humanized non-human animal and its application in the field of biomedicine. The nucleotide sequence encoding human CCR4 protein is introduced into the non-human animal genome by means of homologous recombination. Animals can normally express human or humanized CCR4 protein, which can be used as an animal model for the study of human CCR4 signaling mechanism, drug screening for tumors and immune diseases, and has important application value for the development of new drugs for immune targets. The invention also provides a humanized CCR4 gene, a humanized CCR4 protein and a targeting vector. |
| priorityDate |
2020-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |