| abstract |
The invention discloses a direct reduction cross coupling method of nickel-catalyzed heterocyclic phosphonium salt and aryl bromide and a product thereof, wherein the method comprises the following steps of heating a mixture of magnesium chips and lithium chloride in a nitrogen atmosphere; cooling the mixture to room temperature, and adding an ultra-dry solvent into the mixture; then respectively adding a phosphonium salt compound, a catalyst, a ligand and an aryl bromide, and stirring for reaction; quenching, washing, extracting and drying the reaction product, and separating by column chromatography to obtain an arylated pyridine or diazine compound; the preparation method has the characteristics of mild reaction conditions, simple post-treatment, green steps, low pollution, high economic benefit and the like. |