| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab1481120c9750c1d32aee3d4d9a74a3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4418 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6da1c92e526d935f13742e304a99542c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72bdfbcd3578170db66429ccaeacdda8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4958f06a14621753b2df4037b38b563c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71043a4067a606f16493bc7a6fb28b36 |
| publicationDate |
2021-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113384598-A |
| titleOfInvention |
Composition for improving hepatic fibrosis and preparation method and application thereof |
| abstract |
The invention belongs to the technical field of biological medicines, and particularly relates to a composition for improving hepatic fibrosis and a preparation method and application thereof. The composition comprises a mesenchymal stem cell membrane induced by Hepatocyte Growth Factor (HGF) and a mesenchymal stem cell exosome modified by pirfenidone. The composition has the following functions: preventing the occurrence of hepatic fibrosis; improving fibrosis symptoms such as liver cirrhosis and liver cancer; reducing laminin and hyaluronic acid levels in serum; promoting the degradation of the deposited type I collagen of the liver; reducing CK18-M30 level, and inhibiting hepatocyte apoptosis; is a medicine with good safety and high absorption rate and can effectively treat hepatic fibrosis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113925856-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113925856-B |
| priorityDate |
2021-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |