http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113372344-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2020-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113372344-B |
| titleOfInvention | A kind of synthetic method of chloro six-membered nitrogen-containing heterocyclic imidazole compounds |
| abstract | The invention discloses a method for synthesizing a chloro six-membered nitrogen-containing heterocyclic imidazole compound, and specifically discloses the reaction of compound I with phosphorus oxychloride and an organic base in the presence or absence of a solvent to obtain the compound shown in formula II. The compound shown; wherein, X is N or C(R 3 ); Y is N or C(R 2 ); Z is N or C(R 1 ); R 1 , R 2 and R 3 are independently hydrogen, halogen or C 1 -C 6 alkyl. The synthesis method of the invention is easy to operate, completes the ring closure and chlorination steps in one pot, the used reagents are less polluted, traditional reagents such as chloroacetaldehyde or sulfuric acid are eliminated, and the product yield and purity are obviously improved. |
| priorityDate | 2020-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.