http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113368259-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6939 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5161 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 |
| filingDate | 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113368259-B |
| titleOfInvention | A method for loading nano-drugs based on modified bacteria and their complexes and their application in the treatment of colon cancer |
| abstract | The invention discloses a method for loading nano-drugs based on modified bacteria, which utilizes supramolecular reaction to load ursolic acid nano-drugs coated with hydroxypropyl cyclodextrin on surface-modified amantadine attenuated Salmonella typhimurium, wherein 1×10 8 CFU surface-modified amantadine-modified attenuated Salmonella typhimurium loaded with 6.5-16.5 mg of ursolic acid nanomedicine comprising ursolic acid and hydroxypropyl cyclodextrin in a molar ratio of 2:1 . The new compound drug prepared by this method not only utilizes the natural hypoxic targeting type of bacteria to transport the drug to the hypoxic area of the tumor core, reduces the loss of the drug in the transport in the body, and significantly improves the availability of the drug; Biological and chemical dual therapy has obvious synergistic efficacy compared with chemotherapeutic drugs + bacterial physical mixed therapy, which can significantly inhibit tumor growth without tumor recurrence. |
| priorityDate | 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.