| abstract |
The invention discloses a betalainn nanoliposome and a preparation method and application thereof. The preparation method comprises: dissolving soybean lecithin and cholesterol in an organic solvent to obtain solution 1; dissolving betalainin in a PBS solution, A betalain solution was obtained; solution 1 was mixed with beta betaine solution, and ultrasonically treated for a short time; the organic solvent was removed by rotary evaporation, and the PBS solution of Tween 80 was added to hydrate under reduced pressure after reaching a colloidal state; ultrasonically treated for a short time again, A betalainn nanoliposome solution was obtained. The liposome prepared by the invention has high stability, and lipid molecules are not easily hydrolyzed or oxidized; the shape is regular, the particle size is small, and it is safe and non-toxic; the EC 50 value of human hepatoma cell HepG2 is compared with that of betalain . The value was increased by at least 18 times, with good antitumor effect. |