http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113368236-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66565b7c482dce504fc00b66fb961376 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-641 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-00 |
| filingDate | 2021-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b4d009b2eb79b49e179ec28b1c4b2d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f78c97ef20ca377f1630a2011e49df9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a79ba996bb42ac503e7ef383abb57ef9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43bdd3178041e6a5667d65936d9b5769 |
| publicationDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113368236-A |
| titleOfInvention | Amphiphilic dendritic polypeptide for photodynamic/NO synergistic anti-biofilm infection and wound healing promotion and preparation method and use thereof |
| abstract | The invention provides a light-responsive amphiphilic dendritic polypeptide for photodynamic/NO synergistic anti-biofilm infection and wound healing promotion, which has a hydrophilic end and a hydrophobic end, and the hydrophilic end is a fourth-generation lysine dendritic polypeptide , and the branch end is loaded with NO donor material; the hydrophobic end is stearic acid, which is grafted to the tail end of the fourth-generation lysine dendritic polypeptide through ethylenediamine, and at the end of the fourth-generation lysine dendritic polypeptide The tail end forms a hydrophobic core, and the hydrophobic core is loaded with a photosensitizer. The invention also provides a preparation method and application of a light-responsive amphiphilic dendritic polypeptide for photodynamic/NO synergistic anti-biofilm infection and wound healing promotion. The light-responsive amphiphilic dendritic permeable bacterial biofilm of the present invention induces the H 2 O 2 produced by the photosensitizer to rapidly oxidize arginine to release a large amount of NO, the photochemical process simultaneously generates singlet oxygen, and realizes photodynamic therapy and NO gas. Combination of therapeutic, synergistic antimicrobial and biofilm ablation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114404364-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114404364-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115006583-B |
| priorityDate | 2021-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.