http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113368235-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1818 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-08 |
| filingDate | 2021-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113368235-B |
| titleOfInvention | A kind of Gd-NGQDs/BTS@PLGA-PEG nanomaterial and its preparation method and application |
| abstract | The present invention relates to a kind of Gd-NGQDs/BTS@PLGA-PEG nano material and its preparation method and application, comprising the following steps: (1) preparing nitrogen-doped graphene quantum dot aqueous solution with uniform dispersion and uniform particle size; (2) Sodium benzothiazole sulfinate and PEG-PLGA were dissolved in dichloromethane by film hydration method, ultrasonically oscillated to make it evenly mixed, and the solvent was removed in vacuum at room temperature to form a film; take the nitrogen-doped Add graphene quantum dot aqueous solution and gadolinium acetate, add ultrapure water, react at 40-60°C for 1-2h, filter through a 0.45μm filter membrane, and store; (3) use a dialysis bag for 48-72h to obtain Gd-NGQDs /BTS@PLGA‑PEG Nanomaterials. Compared with the prior art, the invention can solve the problem of phototoxicity of the sonosensitizer, improve the effect of sonodynamic therapy on tumors, and can realize deep tumor treatment, so as to achieve the synergistic treatment of sonodynamic therapy and sulfur dioxide gas therapy. |
| priorityDate | 2021-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.