http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113365648-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_241368e846e729bde1f41baec4e8972a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94f6fdcc292d2b678f7b0f0e04ae6ee1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_524f4411ca5bed675ebb5ad1937298b1 |
| publicationDate | 2021-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113365648-A |
| titleOfInvention | Complement inhibitors and their uses |
| abstract | The present invention relates to a multimodal polypeptide comprising (i) an Fc receptor binding module; (ii) a first complement regulatory protein repeat (CCP) module; and (iii) a second CCP module that binds to at least a a host cell surface marker, bound to complement factor C3b, bound to complement factor C4b, bound to a degradation product of complement factor C3b and/or bound to a degradation product of complement factor C4b; wherein said second CCP module is said Fc receptor binding module and the C-terminus of the first CCP module. The present invention also relates to polynucleotides encoding said multimodal polypeptides, and to said multimodal polypeptides for use in medicine, in particular for the treatment and/or prevention of inappropriate complement activation and/or inappropriate Complement activation as a symptom of disease. Furthermore, the present invention relates to an in vitro method for preventing or reducing the degree of complement activation, the method comprising applying a multimodal polypeptide to a reaction mixture, tissue and/or organ comprising complement factors, thereby preventing or reducing the level of activation in said reaction The extent of complement activation in mixtures, tissues and/or organs. |
| priorityDate | 2018-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 162.