http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113354696-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-04 |
| filingDate | 2021-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113354696-B |
| titleOfInvention | A kind of preparation method of 7-xylosyl paclitaxel |
| abstract | The invention relates to a preparation method of 7-xylosyl paclitaxel, which belongs to the technical field of preparation of taxane anticancer drugs. The preparation method comprises: S1:7-xylosyl-10-desacetyl paclitaxel extract and two Dissolve methyl chloride and pyridine, add 2,2,2-trichloroethyl chloroformate dropwise under stirring, and react to obtain product I; S2: dissolve product I in methanol and acetic acid, add zinc powder, and stir to obtain product II; S3: the product II is dissolved in tetrahydrofuran, cerium trichloride is added, acetic anhydride is added dropwise, and the reaction is stirred to obtain the product III; S4: the product III is dissolved in methanol, 30% dimethylamine methanol solution is added, and the reaction is stirred to obtain 7‑Xylosyl Paclitaxel. The invention has the advantages of accessible starting materials, mild reaction conditions, high purity of the target product, and large-scale preparation. |
| priorityDate | 2021-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.