| abstract |
The invention relates to the field of natural medicines, and discloses an isopentenyl substituted coumarin compound with a novel chemical structure and derived from Polo honey, a preparation method thereof and application thereof in antitumor medicines, wherein the evaluation results of various in vitro antitumor activities of the compound, namely the artoheteronin, show that: the compound has obvious antitumor activity, has the activity of inhibiting protein tyrosine kinase equivalent to that of a positive contrast medicament, can be further developed into an antitumor medicament taking the protein tyrosine kinase as a target, can be applied to the antitumor medicament, has simple separation and purification process and mild reaction conditions, and has practical significance. |