| abstract |
The invention provides a method for producing combretastatin, which comprises the following steps: mixing lithium chloride and 4, 4-dimethyl-3, 5, 8-tri Bicyclo [5,1,0 ]]Reacting octane with 1,4,7, 10-tetraazacyclododecane represented by the following formula 1 to obtain a cobutrol intermediate represented by the following formula 2; reacting the combretastatin intermediate represented by formula 2 with chloroacetic acid to obtain butol represented by formula 3 below; the butonol represented by formula 3 is reacted with calcium ions to obtain combretastatin represented by formula 4 below. |