http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113337468-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-2304 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2509-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-079 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2021-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113337468-B |
| titleOfInvention | A kind of bifunctional exosome and its preparation method and its application in stroke repair |
| abstract | The invention provides a bifunctional exosome, its preparation method and its application in stroke repair. In the present invention, the DA7R polypeptide and the SDF-1 factor are respectively modified with azide groups through the amidation reaction; secondly, the DBCO group is introduced on the surface of the exosomes through the addition reaction of succinimide and amino groups to construct the DBCO-exocrine Finally, DA7R-SDF-1 double-modified functionalized exosomes were constructed by copper-free click chemistry. The bifunctional exosomes obtained by the method of the present invention show the characteristics of targeting damaged blood vessels at the stroke site and recruiting neural stem cells, thereby enhancing their ability to induce neural stem cells to differentiate into neurons, and finally through the "integrated multifunctional exosomes""Exosomes achieve neural repair. The present invention paves the way for exosome-based CNS injury therapy and the rational design of functionalized exosomes. |
| priorityDate | 2021-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.