| abstract |
The invention discloses a repair-promoting double network hydrogel and a preparation method and application thereof. The preparation method includes the following steps: (1) digesting the decellularized corneal stroma after freeze-drying treatment, adding phosphate buffer to obtain the decellularized corneal stroma hydrogel solution; (2) preparing modified hyaluronic acid or modified gelatin Dissolved in the initiator solution, mixed with the decellularized corneal stroma hydrogel solution, added with a cross-linking agent, mixed well, and irradiated with ultraviolet light to obtain a repair-promoting double network hydrogel. The repair-promoting double-network hydrogel has good fluidity before gelation, can quickly fill corneal wounds, has good light transmittance and tissue adhesion, does not need to obtain precise dimensions in advance, and does not require sutures; components simulate tissue microenvironment, It is beneficial to cell adhesion and growth; it has stable structure, high mechanical strength and slow degradation; it can be used as corneal wound adhesive, corneal perforation sealing agent and non-stitched lamellar cornea substitute. |