Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-755 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0008 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-864 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
filingDate |
2021-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2022-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2022-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-113336841-B |
titleOfInvention |
F8 protein variant and gene therapy vector prepared by using the same |
abstract |
The present invention provides the F8 protein variant and the gene therapy vector prepared by using the same. The F8 protein variant is any one of the amino acid sequences obtained by deleting at least 4 amino acids of the BDDF8-N6 variant; wherein, the deleted amino acids include the furin recognition site RHQR. The F8 protein variant provided by the present invention is based on the BDDF8-N6 variant, the B structural domain is optimized, the F8 protein furin recognition site and the amino acids in its vicinity are deleted, and a new high-efficiency variant is obtained. The variant vector has increased titer and higher activity of F8 in in vivo tests, which has high clinical translation value. |
priorityDate |
2021-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |